TNF and metabolic syndrome: The main findings of the study were: (1) CR-TRS patients with MetS exhibited poorer cognitive function compared to those without MetS; (2) TNF-α levels were significantly higher in CR-TRS patients with MetS compared to those without MetS, showcasing promising pathophysiological potential for identifying CR-TRS patients with MetS; (3) in CR-TRS patients without MetS, IL-2 emerged as an independent contributor to the psychiatric symptom and general psychopathology subsymptoms.