The current study showed that Cx3cr1+Ccr2+ Mo-macs expressed the adaptor Myd88 and activated the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway, resulting in the activation of HSCs and thereby promoting the progression of inflammation and liver fibrosis. This evidence concerns the gene NFKB1 and Hepatic fibrosis.