During the evolution of steatosis-MASH-hepatic fibrosis, hepatocytes experience a series of important molecular events, such as somatic mutation selection,57 accumulation of epigenetic modifications, and changes in the dynamic signal regulation network.58,59 In this study, we observed the aberrant expression of the RNA m6A methyltransferase METTL14, indicating that RNA m6A modification is involved in steatosis/MASH-related inflammatory-cancer transformation. This evidence concerns the gene METTL14 and metabolic dysfunction-associated steatohepatitis.