Alongside resolving UTI-driven, mammary-specific ECM remodeling, TIMP1 neutralization also decreased the abundance of mammary infiltrating CD11bhiLy6G+ neutrophils by 53% compared to control IgG-treated UTI-bearing mice, in contrast to other circulating and mammary infiltrating immune cells populations, which remained unchanged (Fig. 5J, Supp. The gene discussed is TIMP1; the disease is bacterial urinary tract infection.