Further analysis of receptor-ligand pairs predicted that Itga9-Itgb1 pairing was predominant between NPF1 and NPF2 fibroblasts, and major MEC subtypes in the mammary tissue of UTI-bearing mice, while Itgav-Itga8 pairing was more frequent between NPF1 fibroblasts and MECs in the non-UTI mammary tissue (Fig. 2H, I). Here, ITGAV is linked to bacterial urinary tract infection.