GPT and brain infarction: Four patients did not receive regular adjuvant therapy, and the reasons were: pts no. 2, discontinued after 4 cycles due to cerebral infarction; pts no. 6, discontinued after 3 cycles due to covid-19 pneumonia; pts no. 8 chose active surveillance due to poor liver function, and pts no. 12 chose active surveillance due to SAE of increased ALT/AST during the neoadjuvant therapy.