Although there was no enrichment of specific myeloid cell types (macrophages, dendritic cells, mast cells) in either group, differential gene expression revealed the high UMIS myeloid cells had upregulated genes involving CD8+ T cell recruitment (CXCL10, CXCL9), tumor phagocytosis (SLAMF7), antigen processing (TAP1, TAP2), antigen presentation (HLA-A, HLA-B, HLA-C, B2M, HLA-DPB1, HLA-DQB1, HLA-DRB1) and interferon response (IRF1, IRF8, IFI27, IFI6) (Fig. 4g; Supplementary Fig. 5d and Supplementary Data 11)24,25,28–31. The gene discussed is IRF8; the disease is neoplasm.