MITF and melanoma: Our findings confirmed a strong association between SNHG7 and CTNNB1 expression level in UM metastases (n = 100) (Fig. 4l) that was independent of tumor cell abundance as measured by melanoma-specific gene expression (S100A1, SOX10, MITF) and total RNA quantity (ACTB, GAPDH) (Fig. 4m and Supplementary Fig. 6c).