Metastases with low UMIS (versus high UMIS) had a paucity of TIL and were composed of tumor cells with higher beta-catenin transcript expression (CTNNB1), which has been described as a transcriptional repressor of BATF3-lineage dendritic cell recruitment of CD8+ T cells30,50,51. This evidence concerns the gene CTNNB1 and neoplasm.