B2M and neoplasm: Differential gene expression revealed high UMIS tumor cells had significantly increased expression of several interferon-inducible transcription factors and elements (IRF1, IFI27, IFI6, IFITM1, IFITM2, IFITM3) and each of the major histocompatibility complex (MHC) class I molecule heterodimer components (HLA-A, HLA-B, HLA-C, B2M) (Fig. 4h, i; Supplementary Fig. 6b and Supplementary Data 12)23–25.