In contrast, high UMIS metastases had lower tumor cell expression of CTNNB1, increased APC expression of T cell chemoattractant ligands (CXCL10 and CXCL9), greater tumor reactive TIL recruitment, and markedly elevated MHC expression on multiple cell populations within the tumor microenvironment, suggesting prominent interferon signaling. This evidence concerns the gene HLA-C and neoplasm.