CTNNB1 and cancer: Interestingly, the most upregulated gene in low UMIS tumor cells was the long non-coding RNA, SNHG7, which was 3.48-fold upregulated in low UMIS tumor cells (log2(fold change) = −1.80, FDR ~ 0) and has been previously reported as a positive regulator of CTNNB1 expression in several cancers (Fig. 4h, i and Supplementary Data 12)34–38.