Despite the high prevalence of the GJB2 c.35del variant and the fact that hearing loss is the most prevalent sensorineural disorder in humans and a major health concern worldwide (Batissoco et al., 2022; Lezirovitz and Mingroni-Netto, 2022), the pathogenetic pathway from GJB2 loss of function to hearing loss is still unclear (Smith et al., 2024). The gene discussed is GJB2; the disease is hearing loss disorder.