According to the scientific literature, these missense variants may protect against alcohol dependence (ADH1C, rs698), type 2 diabetes (T2D) (PPARG, rs1801282; SLC30A8, rs13266634), coronary heart disease (CHD) (ZC3HC1, rs11556924), obesity (SH2B1, rs7498665), and oesophageal cancer (PLCE1, rs2274223). This evidence concerns the gene SH2B1 and obesity due to melanocortin 4 receptor deficiency.