SCN9A and neuropathic pain: For instance, the Na+ channel subtype Nav1.7 is exclusively expressed in the nociceptive pathways of the PNS and regulates the action potential threshold, which causes an enlarged persistent sodium current associated with SNI‐induced neuropathic pain, STZ‐induced diabetic neuropathic pain, and inflammatory pain.[39, 51, 52]KCa channels modulate neuronal firing frequency and AHP, generating an outward current that prevents neuronal hyperexcitability.[53, 54] However, these channels have not been thoroughly studied in the context of PDNP.