The inhibition of both TREK1 and TREK2 channels may induce hyperexcitability in trigeminal sensory neurons, leading to migraine‐like symptoms in rodents.[25] Additionally, visceral inflammation could increase neuronal mechanosensitivity by reducing the expression of TREK1 and TREK2 mRNA in DRG neurons.[62] Given the established importance of TREK1 and TREK2 in nociception, we investigated the expression and functionality of these channels in peripheral sensory neurons in the context of our PDNP study. This evidence concerns the gene KCNK2 and migraine disorder.