These results are consistent with those of other neuropathic pain animal models, which showed that the activation of TREK1 and TREK2 reverses migraine‐like cutaneous allodynia and SNL‐induced mechanical allodynia in rodents.[26, 59] However, our study provides novel evidence for alleviating thermal hyperalgesia induced by PDN through activation of TREK1 and TREK2 channels. This evidence concerns the gene KCNK2 and migraine disorder.