ISG15 and neoplasm: LncRNAs act as scaffolders in regulating the stability, localization, and activity of binding proteins in the nucleus or cytoplasm in a dose‐dependent manner.[29] To investigate whether PCAT6 could function as a scaffold for ISG15 and hnRNPA2B1, we confirmed the protein–protein interaction between ISG15 and hnRNPA2B1 in hypoxic tumor cells using a co‐immunoprecipitation (co‐IP) assay (Figure 4c).