Similar findings were also reported for Atp13a3 in CHO-MG cells, although unlabelled SPD and SPM competed with ATP13A3-dependent PUT-BDP uptake.14 However, ATP13A3 loss in pancreatic cancer cells prevented the uptake of radiolabelled SPD and SPM, with little effect on PUT uptake.15 Whether the polyamine specificity of ATP13A3 differs in a cell-dependent manner or if the methods of ATP13A3 manipulation exert different effects have yet to be established. The gene discussed is ATP13A3; the disease is familial pancreatic carcinoma.