Consistent with our previous studies, in vehicle administered mice, IAV compared to mock infection resulted in the increase of expression of several inflammatory related genes within the vagal sensory ganglia, Tmem173 (fold change: day 8, 2.21 ± 0.26, p < 0.05), Il1b (fold change: day 8, 6.27 ± 1.52, p < 0.05), Irf9 (fold change: day 4, 2.07 ± 0.17, p < 0.01; day 8, 2.44 ± 0.14, p < 0.0001), and Isg15 (fold change: day 8, 12.26 ± 3.43, p < 0.01). This evidence concerns the gene ISG15 and infection.