Similar to surgical vagotomy, cellular ablation of nodose pulmonary afferents did not appear to impact body weight or respiratory function in Phox2B-Cre+ mice compared to Phox2B-Cre- mice prior to infection (S6A and S6B Fig) and no differences in body weight and lung immune cell populations were observed in mock infected Phox2B-Cre+ and Phox2B-Cre- mice (S7A and S7B Fig). The gene discussed is PHOX2B; the disease is infection.