Of the 42 candidate proteins expressing genes, 16 (ANG, CD27, CDH3, CKAP4, COL6A3, GFRA1, HAVCR1, IGFBP4, IGFBP6, LTBR, NEFL, TINAGL1, TNFRSF21, TNFRSF4, VSIG4, WFDC2) genes were significantly correlated with CKD and kidney fibrosis in general populations (Supplementary Table S4 (16)) (21). This evidence concerns the gene CDH3 and chronic kidney disease.