Of the 42 candidate proteins expressing genes, 16 (ANG, CD27, CDH3, CKAP4, COL6A3, GFRA1, HAVCR1, IGFBP4, IGFBP6, LTBR, NEFL, TINAGL1, TNFRSF21, TNFRSF4, VSIG4, WFDC2) genes were significantly correlated with CKD and kidney fibrosis in general populations (Supplementary Table S4 (16)) (21). Here, TNFRSF21 is linked to chronic kidney disease.