It can also suppress the protein expression of TNF-α/IL-1β/IL-6 in serum of colitis mice (p < 0.001, p < 0.001, p = 0.003), the mRNA expression of JAK2/STAT3 (p = 0.028, p = 0.038), the protein expression of JAK2/STAT3 (p = 0.007, p < 0.001) and the phosphorylation level of JAK2/STAT3 (p < 0.001, p < 0.001) in colonic tissue of DSS-induced UC mice treated by Rau (Fig 7H–7N). This evidence concerns the gene TNF and colitis.