This might be due to Plasmodium infection causing endothelial dysfunction, which is the system used for the synthesis of substances involved in coagulation and fibrinolysis, including von Will brand factor (vWF), tissue plasminogen activator, plasminogen activator inhibitor, and protein S. Those lead to activation and consumption of coagulation factors, which results in prolonged PT, APTT and INR [45–47]. This evidence concerns the gene VWF and endothelial dysfunction.