KLK3 and neoplasm: Importantly, this association between nuclear ERα (active) status and BCR remained significant when the model was adjusted for other variables associated with BCR in multivariate analyses, such as the Gleason score, tumor stage, prostate-specific antigen (PSA) levels at diagnosis, nodal invasion status, and surgical margins (HR for positive nuclear ERα: 3.02; Figure 1F; right).