TNF and inflammatory bowel disease: To date, a number of studies have reported favorable effects of anti-TNF therapy on the extraintestinal manifestations of IBD.14,15,16 Despite this, studies investigating the effect of anti-TNF therapy on survival for patients with IBD are limited, and to our knowledge, no prior studies have assessed its effect on the risk of CKD progression, a well-known extraintestinal manifestation of IBD and an established risk factor for mortality,17,18 in these patients.