Barnett et al. [31] has demonstrated mucin deficiency in patients using dupilumab, while Bakker et al. [32] has documented a paucity of conjunctival goblet cells along with increased T-cell and eosinophilic infiltrates in conjunctival biopsies of AD patients diagnosed with dupilumab-associated conjunctivitis. This evidence concerns the gene MUC5AC and Alzheimer disease.