It should be noted that B7-H3 is overexpressed on differentiated malignant and cancer-initiating cells in many different cancer types (Roth et al. 2007; Zang et al. 2007, 2010; Crispen et al. 2008; Boorjian et al. 2008; Lemke et al. 2012; Ingebrigtsen et al. 2014; Sun et al. 2014; Bachawal et al. 2015; Inamura et al. 2018; Pulido and Nunes-Xavier 2023), while its expression level is low in most normal organs and tissues (Modak et al. 2001) making it an attractive molecular target for diagnostic and/or treatment applications. This evidence concerns the gene CD276 and cancer.