NCKAP1 and neoplasm: Studies show that NCKAP1 drives the actin assembly and polymerization as well as the formation of lamellipodia, which is essential for cell motility and adhesion (Steffen et al. 2004; Teng et al. 2016; Xiong et al. 2019), and this is associated with the development of tumor invasive and metastatic phenotypes.