For example, MTDH was tightly related to advanced tumor grade and stages in patients with colorectal cancer (CRC) (Sultan et al. 2021), and could enhance CRC cell proliferation, anaerobic glycolysis and stemness via activating NF-ĸB pathway (El-Ashmawy et al. 2019). The gene discussed is MTDH; the disease is colorectal carcinoma.