MTDH and cancer: Metadherin (MTDH, also known as LYRIC and AEG-1) is a well-known oncogene that allows cancer cells to adhere closely to blood vessels to metastasis (Hu et al. 2009), moreover, MTDH protein promotes angiogenesis and confers chemoresistance (Liu et al. 2009; Yoo et al. 2009).