MAPT and Alzheimer disease: The link with AD was then strengthened by subsequent investigations, which highlighted the association occurring with AD-related tau and amyloid pathology, both assessed through Positron Emission Tomography (PET) (Dahl et al. 2021; Jacobs et al. 2021, 2023; Calarco et al. 2022; Van Egroo et al. 2022).