Briefly, physical examination remains useful to select patients requiring imaging evaluation, testing for TSH (with or without free-T3 and free-T4) is needed to assess thyroid function, US is recognized as the pivotal imaging procedure to assess the risk of malignancy of any TN, TS by using sodium-iodide symporter (NIS) targeting tracers (TSn), such as 123I natrium (sodium) iodide (123I) or 99mTc-natrium (sodium) pertechnetate (99mTcO4-), is indicated when AFTN-related (clinical or subclinical) hyperthyroidism is suspected [17]. Here, SLC5A5 is linked to hyperthyroidism.