Based upon the finding that MIDN promoted proteasome-mediated degradation of IRF4 (Gu et al., 2023), and reports that IRF4 promoted c-Myc expression necessary for myeloma cell survival (Shaffer et al., 2008), we analyzed IRF4 and c-MYC levels in MidnKD/KD splenic B cells by immunoblot. The gene discussed is IRF4; the disease is plasma cell myeloma.