BCL2 and B-cell chronic lymphocytic leukemia: Eμ-BCL2 mice occasionally develop lymphomas (Strasser et al., 1993); moreover, in humans, a chromosomal translocation linking the IGH and BCL2 loci is associated with B lymphomas and CLL (Adachi et al., 1990; Tsujimoto et al., 1985), and BCL2 is typically overexpressed in CLL (Calin et al., 2008; Kitada et al., 1998).