Although most genes did not share their expression pattern between these tissues and CD4 + T-cells, a subgroup of genes was dysregulated in all three, including the novel LXR target UGCG [8] (Fig. 2H), supporting that glycosphingolipid as well as cholesterol metabolism may be important in people with RRMS. This evidence concerns the gene UGCG and relapsing-remitting multiple sclerosis.