Other genes involved in cellular homeostasis of cholesterol (including EEPD1 which positively regulates ABCA1-mediated cholesterol efflux) [32] (Fig. 2F and Supplementary Table S5), and glycosphingolipids (Supplementary Table S6), were also differentially expressed, supporting a global dysregulation of lipid metabolism in CD4 + T-cells from RRMS patients (Supplementary Fig. S3C). Here, EEPD1 is linked to relapsing-remitting multiple sclerosis.