Examples of other differentially regulated genes identified in this analysis and known to play a role in RRMS pathogenesis include tyrosine kinase 2 (TYK2); a polymorphism of TYK2 (rs34536443 variant) is an established genetic risk factor for MS and T-cells expressing the protective TYK2 (GC) genotype have decreased TYK2 activity associated with a TH2 cytokine profile compared with the MS-associated TYK2 (GG) genotype [66]. Here, TYK2 is linked to myeloid sarcoma.