Furthermore, the gene expression pathways enriched in this study, including lipid metabolism, cytokine signalling, signalling by nuclear receptors, and response to stimuli, were also identified in an independent gene expression dataset comparing CD4 + T-cells from RRMS patients with HCs, (Supplementary Fig. 3A-B) [27]. This evidence concerns the gene CD4 and relapsing-remitting multiple sclerosis.