ACE2 and heart failure: Young, healthy, and physically fit individual will tend to express more of angiotensin 1-7 which allows for regulation of the pathway and cleavage of ACE2 by enzyme sheddase, leading to less expressions of the ACE2 receptor required for the entry of SAR-CoV-2, unlike in older individuals who have higher risks of developing hypertension, diabetes, heart failure etc., which activates the production of more angiotensin II necessary for higher expression of ACE2.