In another study aiming to understand the role of the NLRP3 inflammasome in Th1/Th2 responses during leishmaniasis, knockout BALB/c mice for NLRP3, ASC, or caspase-1, displayed deficient IL-1β and IL-18 production and were resistant to cutaneous L. major infection. The gene discussed is IL18; the disease is leishmaniasis.