COL3A1 and Ehlers-Danlos syndrome, vascular type: Various features of the appearance of individuals with vEDS are likely to be explained by the expression of COL3A1 in the following tissues: (1) smooth muscle cells (varicose veins), (2) skin (easy bruising, translucent skin, gingival regression/fragility, lobeless ears, and acrogeria) and (3) bone marrow plus connective tissue (prominent [sunken] eyes and narrow nose; https://www.proteinatlas.org/ENSG00000168542-COL3A1/tissue).