COL3A1 and Ehlers-Danlos syndrome, vascular type: Interestingly, COL3A1-deficient, haploinsufficient, and glycine-mutant vEDS mouse models have been reported to show similar features as vEDS patients.28–32 Overexpression of COL3A1 with a variant at the N terminus showed reduced collagen in the aortic adventitia with fibrils highly variable and increased in diameter, similar to those found in the deficiency models.