It is suggested to offer genetic analysis including the COL3A1 gene in all individuals with a dissection or unexplained aneurysm under the age of 50 years, or 60 years in the absence of hypertension.34 A previous study on the diagnostic yield of the thoracic aortic aneurysms and dissections genes showed a P/LP COL3A1 variant in 6 of 810 individuals (0.7%), including 2 individuals in the age range of 50 to 60 years.35 The gene discussed is COL3A1; the disease is thoracic aortic aneurysm.