PTGDS and COVID-19: Expression of inflammatory hubs responsible for restricting inflammation, such as ChoE-18 : 3, LPC-O-16 : 0, and PC-O-30 : 0, is decreased in patients with sepsis from COVID-19, while expression of inflammatory hubs responsible for enhancing inflammation, such as sPLA2, PGD2, and 12-HETE, is increased in patients with sepsis from COVID-19 as reported by Meng et al.141 Data from a multi-omics approach using proteomics, metabolomics, and lipidomics were applied to build a workflow to predict aggravation of COVID-19 symptoms of patients in the ICU.