In the case of NAFLD, ApoE and lymphocyte cytosolic protein 1 (LCP1) were significantly upregulated, while IGFBP3 and vitamin D-binding protein were downregulated in patients with NASH compared with healthy subjects.102 In the exploration of the mechanism underlying MetS, proteomics has enabled significant advances. This evidence concerns the gene LCP1 and metabolic dysfunction-associated steatotic liver disease.