In the case of NAFLD, ApoE and lymphocyte cytosolic protein 1 (LCP1) were significantly upregulated, while IGFBP3 and vitamin D-binding protein were downregulated in patients with NASH compared with healthy subjects.102 In the exploration of the mechanism underlying MetS, proteomics has enabled significant advances. The gene discussed is LCP1; the disease is metabolic dysfunction-associated steatohepatitis.