SHBG and type 2 diabetes mellitus: Several previous studies reported possible protective associations between T2D risk and SHBG, which is a hepatokine that binds to circulating steroid hormones (testosterone, oestradiol) and acts on macrophages and adipocytes to suppress inflammation and lipid accumulation.30 Although the associations of SHBG with T2D became borderline significant after multiple testing correction (HR per SD higher: 0.69 [0.56-0.85]; 5% FDR P=0.057), the present results were consistent with previous study findings.