The ENTR1 gene encodes the endosome associated trafficking regulator 1, which has a potential role in the transcriptional regulation of the solute carrier family 2 member 1 glucose 40 transporter protein (SLC2A1).36 Importantly, SLC2A1 is responsible for approximately 30−40% of the glucose uptake in skeletal muscle, with the remainder transported through GLUT4.36 This may partially explain the strong and apparently causal associations with T2D observed in the present study. This evidence concerns the gene SLC2A1 and type 2 diabetes mellitus.