LPL (Lipoprotein lipase) is a rate-limiting enzyme that hydrolyzes circulating triglyceride-rich lipoproteins including very low-density lipoproteins and chylomicrons.34 This enzyme is predominantly located in adipose tissue, muscle and cardiac tissue, and a reduction in LPL activity is associated with an increase in plasma levels of triglycerides, prompting evaluation of target druggability for treatment of dyslipidemia,34 but its relevance to insulin resistance and glucose metabolism is less clear. Here, INS is linked to metabolic syndrome.