SHBG and type 2 diabetes mellitus: Previous observational studies of proteomics and T2D have involved primarily European ancestry populations, used different study designs, and included varying number of proteins measured by different assay platforms.13, 15, 16, 20 Although there were inconsistent findings, several proteins have been consistently associated with T2D, including IGFBP1, IGFBP2, GHR and SHBG.12, 13 In the present study, observational analyses found that IGFBP1 and IGFBP2 were most strongly associated with T2D.