ENTR1 and type 2 diabetes mellitus: The ENTR1 gene encodes the endosome associated trafficking regulator 1, which has a potential role in the transcriptional regulation of the solute carrier family 2 member 1 glucose 40 transporter protein (SLC2A1).36 Importantly, SLC2A1 is responsible for approximately 30−40% of the glucose uptake in skeletal muscle, with the remainder transported through GLUT4.36 This may partially explain the strong and apparently causal associations with T2D observed in the present study.