INS and type 2 diabetes mellitus: Previous MR analyses suggested potential causal effects of LPL on insulin levels and the development of T2D.33 Moreover, a pharmacological study involving 392,220 Europeans showed that triglyceride-lowering alleles in the LPL were associated with lower risk of T2D, independent of LDL-C lowering genetic mechanisms.35 These findings provide genetic support for the development of agents that enhance LPL-mediated lipolysis for T2D prevention, which suggests, if further confirmed in other studies, potential opportunities for drug-repurposing for the treatment of T2D.