An assessment of gut microbiota and innate immune responses in IgE-associated eczema has revealed that the number of Ruminococci in the stools of children with AD is lower than that of healthy controls, and Ruminococci has a negative correlation with TLR2-induced IL-6 and TNF-α, while Enterobacteriaceae is positively correlated with TLR4-induced TNF-α [48]. Here, IGHE is linked to Alzheimer disease.