SPDL1 and metastatic malignant neoplasm in the lymph nodes: Liu et al. noted that the expression of SPDL1 was upregulated in esophageal carcinoma (ESCA) tissues and was related to age, grade, lymph node metastasis, cancer stage, and poor prognosis in patients with ESCA; they also reported that silencing of SPDL1 impeded the proliferation, migration, and invasion of cells [55].