,48 IL-4 can induce allergen-specific B lymphocytes to produce IgE;49 IL-5 can evoke eosinophilic inflammation by recruiting eosinophils;50 IL-4 and IL-13 can induce mucus hypersecretion and goblet cell metaplasia,51 their collaborative action with IL-5 fosters airway hyperreactivity,52 while their synergistic effect with transforming growth factor (TGF)-β and IL-6 facilitates airway remodeling.53 This evidence concerns the gene TGFB1 and Irritability.