“Type-2-high” asthma, including AA,43 often involved an atopic response with Th2-predominant inflammation (associated with the release of IL-4, IL-5, and IL-13)44,45 and marked by elevated levels of inflammation markers such as C-reactive protein, IL-6, and total immunoglobin E (IgE).46 The gene discussed is CRP; the disease is asthma.