The IVW-MR analysis provided suggestive evidence for the association between PCSK9-mediated LDL-C reduction and risk of AA (odds ratio [OR] = 1.31, 95% confidence interval [CI] = 1.11–1.56; P < 0.01), AD (OR = 1.20, 95% CI = 1.05–1.36; P < 0.01), and AR (OR = 0.83, 95% CI = 0.72–0.96; P = 0.01). The gene discussed is PCSK9; the disease is Alzheimer disease.