Intraperitoneal administration of GM1 ganglioside to the APP/PS1 mouse model exhibited a reduction of the Aβ-40 and Aβ-42 [33]; however, a recent study showed that intraperitoneal GM1 administration caused pathological abnormalities in APP/PS1 mice and failed to rescue cognitive decline [36]. Here, PSEN1 is linked to Mental deterioration.