Since GD1a and GT1b gangliosides are ligands for myelin-associated glycoprotein (MAG) which is an inhibitor of nerve regeneration, administration of rHIgM12 targeting GD1a and GT1b could prevent MAG-induced suppression of axonal development and repair, thereby enabling neurons to regenerate in mice models of ALS [45]. The gene discussed is MAG; the disease is amyotrophic lateral sclerosis.