TP53 and neoplasm: The top GO terms contained many tumor proliferation or metastasis-associated pathways, such as signal transduction by p53 class mediator [69] (GO:0072331; BH-adjusted p-value = 1.57e − 6) and regulation of canonical Wnt signaling pathway [71] (GO:0060828; BH-adjusted p-value = 2.81e − 3), suggesting epithelial cells proliferation towards tumor cells; Mixed TDEseq identified a total of 3,671 recession-specific temporal expression genes, which were enriched in 276 GO terms (Fig. 4G).