Consistent with this, a recent study using single‐cell genomic profiling of human dopaminergic neurons revealed high expression of the AT1 receptor gene as a marker of most vulnerable dopaminergic neurons in humans, including PD patients, which are located in the ventral tier of the SN pars compacta (SNpc) [90], further supporting the potential role of the pro-oxidative AngII/AT1 receptor axis in dopaminergic degeneration, as detailed below. Here, AGTR1 is linked to Parkinson disease.