While we have information on serum IL-26 levels only and are unable to speculate further on key sources of production given the many potential sources previously cited by us and others [11–19], our results raise the question of whether these observations indicate that the cellular sources of IL-26 have been recruited into the airways in severe asthma, or whether elevated systemic IL-26 levels per se may confer a protective effect against the development of severe asthma in allergen-sensitized children. Here, IL26 is linked to asthma.