Furthermore, numerous researchers around the globe are actively engaged in clinical investigations pertaining to HER2-targeted CAR-T cells (NCT03198052, NCT01935843, NCT02713984, NCT03740256, and NCT04660929), PD-L1-targeted CAR-T cells (NCT03060343, NCT03330834), CEA-targeted CAR-T cells (NCT02349724 and NCT04348643), as well as B7-H3-targeted CAR-T cells (NCT04864821 and NCT03198052) in lung cancer. The gene discussed is CEACAM5; the disease is lung carcinoma.