METTL1 and hepatocellular carcinoma: They also discovered that METTL1-mediated m7G tRNA modification enhances malignant expression in HCC cells after sublethal heat stress in various experimental models, including patient-derived HCC xenograft (HCC-PDX) mouse models, patient HCC tissues, sublethal-heat-treated HCC cell line model, and HCC patient-derived organoids.