Based on the analysis of small RNA NGS data, Liu et al. [153] revealed that 5’-tRFCys, derived from the 5’half of cysteine tRNA, is overexpressed during BC progression and metastasis, enhances the stability of target transcripts via promoting the binding of nucleolin to its 5’UTR, and protects target transcripts from exonucleolytic degradation by promoting the oligomerization of nucleolin. The gene discussed is NUCLEOLIN; the disease is breast cancer.