Calcium/phosphorus homeostasis-related parameters such as fibroblast growth factor 23 (FGF23) and α-klotho have been implicated in atherosclerosis [7–10], among which FGF23 was synthesized and secreted mainly by osteocytes and was primarily known for its roles in regulating phosphate and vitamin D metabolism [11], and klotho (a co-receptor of FGF23) is a low-molecular-weight type I transmembrane protein, mainly consisting of α-klotho protein and β-klotho protein, which is expressed in the distal convoluted tubules of the nephrons and certain brain regions and co-acted with FGF23 [12, 13]. Here, KL is linked to atherosclerosis.