The AUC of age, LAD and HTN were 0.62 (95% CI 0.47–0.76, P = 0.161), 0.77 (95% CI 0.62–0.89, P < 0.001), and 0.64 (95% CI 0.49–0.77, P = 0.092), the recognized clinical risk factors for AF, were lower than the GPR43–NLRP3 score. Here, NLRP3 is linked to hypertensive disorder.