SOS1 and non-small cell lung carcinoma: To further elucidate the mechanism of action of the DNMT1/miR-152-3p/SOS1 axis in the NSCLC, A549-derived LCSLCs were treated with shDNMT1, miR-152-3p-mimic, and siSOS1 to assess their effects on DNMT1, miR-152-3p, and SOS1 levels, as well as CSLC features in A549-derived LCSLCs.