Visceral fat is metabolically active; the oxidative process perpetuates an inflammatory response in the subendothelial space, as activated cells secrete pro-inflammatory molecules, including free fatty acids, adiponectin, and adipocytokines such as TNF-α and IL-6, which cause pro-inflammatory damage and reactive oxygen species production resulting in disease states like hypertension [63]. The gene discussed is TNF; the disease is Hypertension.