Collectively, the above results suggested that exercise could activate anti-tumor immunity to inhibit tumor growth by multiple pathways, such as inducing chemokines and cytokines especially Ccl5 and Cxcl10, to promote CD8+ T cell recruitment, and regulating the expression of PD-L1 and p53 to mediate the anti-tumor effect. The gene discussed is TP53; the disease is neoplasm.