CD4 and neoplasm: However, there was no significant difference in the degree of CD4+ and CD3+ T cells infiltration in tumor tissues between Ctrl and Ex-post mice (Fig. 2e-f, l-m).The expression of Granzyme B (GZMB), a T cell activation marker [27, 28] in both mouse models was higher than that in the Ctrl mice (Fig. 2g, n).