In family HOU4131 (Fig. 1G), previous analyses revealed a pathogenic variant in ASXL3 (HGNC:29357) in both siblings with spasticity, increased deep tendon reflexes, hirsutism, ID, and neuromotor delay (Supplementary Fig. 5B) who were born into a family reported with an unknown degree of consanguinity [4]. This evidence concerns the gene ASXL3 and Hirsutism.