MAST2 and chronic obstructive pulmonary disease: On the other hand, Rothia mucilaginosa, an airway bacterium recently reported to have an anti-inflammatory role [58], was associated with MAST2 encoding microtubule-associated serine/threonine kinase whose dysfunction is involved in pulmonary vascular remodeling [59], together indicating a possible link between airway vascular structural changes, inflammation and microbial dysbiosis in COPD.