Treatment with antihypertensive medication (HR 1.29, 95% CI 1.17–1.42; P < 0.01), insulin treatment (HR 1.26, 95% CI 1.1–1.43; P < 0.01), and smoking (HR 1.32, 95% CI 1.21–1.44; P < 0.01) were also identified as risk factors associated with a higher risk of incident all-cause mortality among persons with T2D and incident PAD. This evidence concerns the gene INS and peripheral arterial disease.