The results of the univariate analysis showed that HBeAg positivity; tumor size, number, and differentiation; MVI; satellite lesions; capsule invasion; high HBV-DNA load, PT levels, AST levels, AFP (> 400 ng/ml) levels, and NLR levels were significant factors related to higher cumulative risk of HCC recurrence. The gene discussed is F2; the disease is hepatocellular carcinoma.