There was not significant correlation between cytokines level (IL-17) and Mayo score in UC [13] and between IL17 and CDAI [7].In contrast, other studiesshowed that there was a positive correlation between IL-17 in the IBD group and endoscopic activity index in UC and CD in comparison to a relatively matched large control group [14].There wasconfirmation by tissue sample showing more IL-17 expression in the mucosa and serum in IBD patients than control mostly related to altered immune and inflammatory responses in the intestinal mucosa [15]. Here, IL17A is linked to irritable bowel syndrome.