Cardiovascular disorder including atrial septal defect, patent ductus arteriosus, and patent foramen ovale were seen in one patient in each of the following groups CLP1, MINPP1, and CHMP1A. In TBC1D23 group (two patient) atrial septal defect was seen as a cardiac findings. The gene discussed is MINPP1; the disease is Abnormal cardiac septum morphology.