For example, among the anti-cancer drug targets in the BrC11 (Supplementary Table S6), it has been known that high expression of NAMPT (nicotinamide phosphoribosyl transferase) confers the tamoxifen resistance [48] and recently it is discovered that combination therapy of NAMPT inhibition and antiestrogen is effective to reduce breast cancer metastasis [49]. This evidence concerns the gene NAMPT and breast carcinoma.